Pituitary Chromophobe Adenomas: Neurology Metabolism Therapy

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This is an important part of the legacy that he left us. In addition, Dr. The team also focused on the more common neurologic disease multiple sclerosis, taking advantage of Dr. Norton's expertise in lipid chemistry. In pursuing their work, Dr. Korey believed that clues from the bedside could and should be examined at the laboratory bench, and vice versa.

Long a proponent of a multidisciplinary approach to tackling clinical puzzles, in Dr. Korey and Dr. Milton Rosenbaum, chair of psychiatry, sought and received a grant from the NIH to support an interdisciplinary program geared to postdoctoral fellows in the neurosciences. The grant also allowed Dr.


Korey to invite distinguished visiting professors to give lectures and be available for discussions with interested fellows. In addition, it supported research relevant to the nervous system in several departments, as well as providing protected time for young clinician-researchers. This grant continued for 37 years, and served as a key factor in the establishment of Einstein's department of neuroscience. Among Dr. Korey's lasting contributions to the College of Medicine was his role, along with Dr. London, in convincing the dean at the time, Dr.

Marcus Kogel, and Einstein's Board of Overseers that the College of Medicine needed a basic science research building. In the year before his death, Dr. Korey was involved in the details connected to the construction of the Ullmann Research Center for Health Sciences. Unfortunately, during the year that the building was completed, he was diagnosed with pancreatic cancer. He died on September 27, , six months before the new building opened. Ullmann helped expand the research capabilities at Einstein, including providing a home for the first liver center in the United States to receive NIH funding.

Korey with neurology residents and members of the neurology division, in When the members of the neurology department learned that their chair had been diagnosed with pancreatic cancer, they had no idea that in just four months he would succumb to the disease. It had described a product in urine, called retine, as a cure for cancer. Bill Norton. He told us how to make this product and how much urine it was going to take. Colleague Robert Ledeen noted, "People thought we were crazy, but we were on a mission. Our goal was to collect enough of this material so that it might be possible to try this treatment on Saul.

Obtaining the retine from the urine involved an arduous process that included boiling the collected matter down and extracting the by-product. Despite their best efforts, "Saul died before we got any product out that was significant," said Dr. In , the College of Medicine introduced a new faculty award at commencement, the Saul R. Korey Award for Translational Medicine and Science. The award honors the memory of Dr.

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Korey and his continuing influence at the medical school and beyond with regard to neurology, neuroscience and translational medicine. It recognizes a faculty member who exemplifies Dr. Korey's philosophy of conducting collaborative research in the laboratory that addresses questions raised through clinical work with patients.

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When Dr. I'm going back to get my award,' and everyone involved knew what that meant. The legacy of Saul Korey is much broader than our institution. The award at Einstein is one of three honors that have been established to honor Dr. Korey's memory. There also is the Saul R. Korey Lectureship, established in by former Korey collaborator and Einstein faculty member Dr. Robert Terry and administered by the American Association of Neuropathologists.

The AAN award seeks to stimulate interest in the field of neurology as an exciting and challenging profession by offering a highly competitive award for the best essay in experimental neurology, judged on the basis of the quality of the scholarship and on suitability for an audience of general neurologists. The Korey Lectureship honors Dr.

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Korey's vision of an interdisciplinary approach to the study of neurological diseases by basic and clinical scientists that has inspired generations of colleagues and trainees. Terry, who generously contributed a portion of the prize funds to endow the Korey Lectureship, has summarized the qualities of the Korey Lecturer as "someone who has been an active member of the association Korey married Doris Broder in , when he was The couple had three children: Cathie, Suzanne and Barry.

Both Barry and Cathie graduated from Einstein, in the classes of and , respectively. Suzanne is a gifted musician and educator. Although he was initially drawn to neurology, Barry's own calling proved to be in psychiatry. He maintained a practice in Westchester County, and headed the borderline inpatient unit at New York Medical College until his premature death at age 52, on September 13, , of ocular melanoma.

Cathie ultimately attended Einstein and pursued a career in internal medicine after first spending 10 years as a community organizer in New York and in the Midwest. She recalled, "One of my fondest memories as a child was going into my father's lab with him. The family spent every summer in Woods Hole, Massachusetts, where the famous Marine Biological Laboratory is a renowned haven for neurologists and neuroscientists. They were the only female role models in science or medicine that I can remember encountering at that time, and they made a huge impression on me.


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She also remembered an occasion when she was about 7 years old and someone asked her what she wanted to be when she grew up. While Dr. Korey often worked until 1 a. Saturday afternoons meant trips into New York City that culminated in visits at his parents' home at th Street and Broadway.

She added, "We weren't aware of his influence at Einstein so much, but I do recall his compassion. He had a good friend, a talented scientist who was hospitalized with what would ultimately be diagnosed as schizophrenia. The friend felt isolated because of his illness and I remember my father would have him over to dinner and made sure to keep his friend in the fold, involved in discussions of the field. It was very touching. In just eight years, Saul Korey established a tight-knit team of researchers and physician-scientists; many of these individuals remained at Einstein for 20 years or more after his death.

These people carried forward the interdisciplinary approach to examining issues identified at the bedside and applying theories explored in the laboratory.

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Mark Mehler front, right and attending physicians and staff with recent graduates of the neurology residency program Bottom: Current Einstein faculty members, John Foxe, Ph. Looking around Einstein's campus today, there are many things that would surprise Saul Korey. Some, such as the state-of-the-art Michael F. The design of that building, added to the Jack and Pearl Resnick Campus in —45 years after his death—reinforces the multidisciplinary approach to research that he encouraged long before the term "translational medicine" was coined. The interdisciplinary grant that he received in , which continued for 37 years, may also one day return, thanks to the efforts of Drs.

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Steven Walkley and John Foxe. The duo plans to submit a similar grant for Einstein's Rose F. Kennedy Intellectual and Developmental Disabilities Center IDDRC to provide interdisciplinary training for grad students and postdocs, as well as to seek other possible funding.